发明名称 |
PIPERAZINE DERIVATIVE RENIN INHIBITORS. |
摘要 |
The invention relates to substituted 3,4- or higher substituted piperazine compounds, the use thereof for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on activity of renin; pharmaceutical formulations or products comprising said compounds, and/or a method of treatment comprising administering said compounds, a method for the manufacture of said compounds, as well as novel intermediates, starting materials and/or partial steps for their synthesis. The compounds are especially of the formula (I), wherein R1, R2, R11, C, E and D are as defined in the specification. |
申请公布号 |
WO2006128659(A3) |
申请公布日期 |
2007.11.29 |
申请号 |
WO2006EP05107 |
申请日期 |
2006.05.29 |
申请人 |
NOVARTIS AG;NOVARTIS PHARMA GMBH;NIHONYANAGI, ATSUKO;TOYAO, ATSUSHI;IWAKI, YUKI;MASUYA, KEIICHI |
发明人 |
NIHONYANAGI, ATSUKO;TOYAO, ATSUSHI;IWAKI, YUKI;MASUYA, KEIICHI |
分类号 |
C07D403/12;A61K31/496;C07D417/14 |
主分类号 |
C07D403/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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