PYRIMIDINE LOW MOLECULAR WEIGHT LIGANDS FOR MODULATING HORMONE RECEPTORS

摘要

Disclosed herein are small molecule modulators hormone receptors, including agonists and antagonists of luteinizing hormone/choriogonadotropin, follicle stimulating hormone and thyroid stimulating hormone receptors. Exemplary disclosed compounds include those of the formula wherein X is -S(O)_nR⁵; n is 0, 1 or 2; Y is -OR⁶ or -NR⁷R⁸ R¹ and R² independently are selected from optionally substituted lower aliphatic, alkoxy, aralkyl, halogen, H and -OR5, wherein R5 is selected from lower alkyl, H, aralkyl, acyl, alkoxycarbonyl and aminocarbonyl; R³ and R⁴ independently are selected from acyl, alkoxycarbonyl, aminocarbonyl, aralkyl, H, lower alkyl and cycloalkyl; R⁵ is selected from lower alkyl, aralkyl, cycloalkyl and haloalkyl; R⁶ is selected from H, lower alkyl and aralkyl; R⁷ and R8 independently are selected from H, lower alkyl, aralkyl and cycloalkyl.