| 摘要 |
<p>Cloned, i.e. defined, defective interfering (DI) influenza A virus is pro duced in embryonated hens eggs using a method which generates large quantiti es of DI virus material. Cloned DI virus is then used in tests on mice and f errets given a lethal challange of wild-type influenza A virus. When cloned DI influenza A virus is co-administered with a lethal dose of virulent influ enza A virus, mice are protected compared to a control of inactivated cloned DI influenza A virus. Mice which survived the administration of cloned DI i nfluenza A virus and infective challange virus are three weeks later still p rotected against lethal challange with infective virus. Control mice which r eceived only cloned DI influenza A virus and no lethal challange are not pro tected three weeks later on lethal challange with infective virus. A therape utic benefit of administering cloned DI influenza A virus is found when the administration takes place in less than 48 hours after challange with infect ive virus. Cloned DI influenza A virus of one subtype is found to act in viv o as an effective antiviral against the same or any other sub-type of influe nza A virus. The antiviral effect has been found to have both a therapeutic and a prophylactic application against influenza A infection in humans, mamm als and birds.</p> |
