| 摘要 |
Compounds of formula (IA) or (AB) are kinase inhibitors, especially of CDK2, and/or PDK1 and/or CHK1: wherein Ring A is an optionally substituted aryl, heteroaryl, carbocyclic or heterocyclic radical, Alk represents an optionally substituted clivaient C<SUB>1</SUB>-C<SUB>6 </SUB>alkylene radical; n is 0 or 1; Q represents a radical of formula -(Alk<SUP>1</SUP>)p-(X),(Alk<SUP>2</SUP>)<SUB>s</SUB>-Z wherein in any compatible combination Z is hydrogen or an optionally substituted carbocyclic or heterocyclic ring, p, r and s are 0 or 1, and Alk<SUP>1</SUP>, Alk<SUB>2</SUB>, X, are as described in the specification, and R<SUB>1 </SUB>represents a radical 3 4 3 (CYC)<SUB>k</SUB>-(Alk<SUP>3</SUP>)<SUB>a</SUB>-(Y)<SUB>b</SUB>-(Alk<SUP>4</SUP>)<SUB>d</SUB>-B wherein k, a, b and d are 0 or 1, and Cyc, Alk<SUP>3</SUP>, Alk<SUP>4 </SUP>and B are as described in the specification.
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