RNAI MODULATION OF AHA AND THERAPEUTIC USES THEREOF

摘要

The invention relates to a double-stranded ribonucleic acid (dsRNA) for i nhibiting the expression of an Aha gene (Aha1 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in le ngth, generally 19-25 nucleotides in length, and which is substantially comp lementary to at least a part of an Aha gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceuti cally acceptable carrier; methods for treating diseases caused by Aha1 expre ssion and the expression of an Aha gene using the pharmaceutical composition ; and methods for inhibiting the expression of an Aha gene in a cell.