发明名称 COSMETIC FORMULATIONS CONTAINING FLAVONOID DERIVATIVES
摘要 New cosmetic formulations (A) contain one or more flavonoid compounds (I) containing mono- or oligoglycoside groups O-substituted by UV-absorber residues. Some compounds (I) are new. New cosmetic formulations (A) contain one or more flavonoid compounds of formula (I). [Image] Z 1-Z 4, Z 6-Z 10H, OH, MeCOO, 1-18C alkoxy, 1-18C hydroxyalkoxy, or mono- or oligoglycoside residue; dotted line : optional bond; Z 5mono- or oligoglycoside residue, containing at least one O-bonded group Q; Q : 2-phenyl-1H-benzimidazol-5-yl, 2-phenyl-1H-benzimidazol-5-ylsulfonyl (optionally substituted by 1-3 sulfo groups in the benzo ring), 4-(X)-cinnamoyl, 4-(3-(4-t-butylphenyl)-1,3-dioxopropyl)-phenyl, 2-(4-(3-(4-(X)-phenyl)-1,3-dioxopropyl)-phenyl)-propyl, 4-(dimethylamino)-benzoyl, 3-(X 1)-4-(X 2)-5-(X 3)-benzoyl, 3-(4-methylbenzylidene)-camphor-(5 or 6)-yl, 4-(camphor-3-ylidene-methyl)-phenyl, 4-benzoyl-3-hydroxyphenyl, 2-hydroxyphenyl, 3-cyano-3,3-diphenyl-propionyl, quinoxalin-2-yl, quinoxalin-2-ylmethyl or a benzimidazole derivative residue of formula (i); X, X 1-X 3OH, MeCOO, 1-8C alkoxy or monoglycoside residue; n : 0-3; k : 0-4; and M : H, Na or K; provided that one or more of the H atoms in the glycoside residues of Z 1-Z 10may be replaced by acetyl; and one or more of the OH groups in Z 1-Z 10may be sulfated or phosphated. [Image] An independent claim is also included for (I) as new compounds, provided that at least one of the OH groups in Z 1-Z 10is sulfated or phosphated if Z 5is a mono- or oligoglycoside residue substituted by 4-(X)-cinnamoyl or 3-(X 1)-4-(X 2)-5-(X 3)-benzoyl. ACTIVITY : Dermatological; Antiinflammatory; Antiallergic; Antipruritic; Cytostatic. MECHANISM OF ACTION : UV-filter; Antioxidant; Radical scavenger. No biological data given.
申请公布号 EP1363594(B1) 申请公布日期 2007.11.21
申请号 EP20020710842 申请日期 2002.02.06
申请人 MERCK PATENT GMBH 发明人 WIRTH, CORINNA;BUCHHOLZ, HERWIG;CAROLA, CHRISTOPHE
分类号 A61K8/49;A23L1/30;A61K8/00;A61K8/30;A61K8/35;A61K8/40;A61K8/60;A61K8/96;A61K8/97;A61K31/7048;A61K36/18;A61P17/00;A61P29/00;A61P37/08;A61Q17/00;A61Q17/04;A61Q19/00;C07H17/07 主分类号 A61K8/49
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