发明名称 |
Method for cyrstallizing human GSK3 and novel crystal structure thereof |
摘要 |
The invention provides the three-dimensional structure of a construct of human glycogen synthase kinase 3 (GSK3); crystals of a construct of human glycogen synthase kinase 3-beta (GSK3-beta) containing the protein's catalytic kinase domain; a method for crystallizing the protein construct to provide a GSK3 crystal sufficient for structure determination; and a method for using the GSK3 construct's three-dimensional structure for the identification of possible therapeutic compounds in the treatment of various disease conditions mediated by GSK3 activity.
|
申请公布号 |
US2007264699(A1) |
申请公布日期 |
2007.11.15 |
申请号 |
US20070824457 |
申请日期 |
2007.06.29 |
申请人 |
CHIRON CORPORATION |
发明人 |
BUSSIERE DIRKSEN E.;LE VINCENT P. |
分类号 |
C12N9/12;G01N33/50;C07K1/107;C07K14/00;C07K19/00;C12Q1/48;G01N33/15 |
主分类号 |
C12N9/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|