Novel gamma-lactams as beta-secretase inhibitors

摘要

There is provided a series of novel substituted gamma-lactams of Formula (I) wherein R¹, R², R³, R⁴ and R⁵ are defined herein, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein (APP) by beta-secretase and, more specifically, inhibit the production of Abeta-peptide. The present invention is directed to compounds useful in the treatment of neurological disorders related to beta-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.