COMBINATION OF AN ANTI EDB FIBRONECTIN DOMAIN ANTIBODY L19-SIP AND AN ANTI-EGFR ANTIBODY

摘要

The invention relates to a combination (i) of a fusion protein, comprisin g an .epsilon.s2-CH4 domain part and an antibody part, specifically recognis ing the extra domain B of fibronectin (ED-B - fibronectin), and (ii) and an anti-EGFR-antibody and its use for treatment of cancer, in particular head a nd neck cancer, non-small cell lung cancer, prostate cancer, colorectal canc er, ovarian cancer, pancreatic cancer, gastric cancer, and / or breast cance r.