发明名称 |
TRAIL RECEPTOR-BINDING AGENTS AND USES OF THE SAME |
摘要 |
<p>This invention relates generally to the preparation of TRAIL receptor-binding agents and uses of the same. In particular, the present invention relates to the preparation of anti-TRAIL receptor antibodies which recognize a common antigen determinant (i.e., epitope) shared by TRAIL-R1 and TRAIL-R2 receptors and their use for TRAIL receptor detection and modulation of TRAIL receptor-mediated function. The TRAIL receptor-binding agents are useful to induce apoptosis in human cancer cells. These targets may either express one or both TRAIL-R1 or TRAIL-R2. The invention provides for the use of the TRAIL receptor-binding agents of the invention in cancer therapy.</p> |
申请公布号 |
CA2649872(A1) |
申请公布日期 |
2007.11.15 |
申请号 |
CA20072649872 |
申请日期 |
2007.04.29 |
申请人 |
BEIJING COTIMES BIOTECH, LTD. |
发明人 |
YU, ZHENG;ZHOU, MIN;SONG, YANG;JIA, XIANZHAO;SHEN, ENYUN |
分类号 |
C07K16/28;A61K39/395;A61P35/00;C12P21/08 |
主分类号 |
C07K16/28 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|