FUNGICIDAL EFFECT BY REGULATING SIGNAL TRANSDUCTION PATHWAYS
摘要
The present invention concerns methods of treating fungal infections and methods of screening compounds for activity in treating fungal infections. Methods of the invention include using an active compound such as fludioxonil to treat a Cryptococcus neoformans infection. Also included are methods and pharmaceutical compositions useful for treating fungal infections using a Hog1 activator such as fludioxonil and a calcineurin inhibitor in combination.
申请公布号
WO2007002120(A3)
申请公布日期
2007.11.15
申请号
WO2006US24031
申请日期
2006.06.22
申请人
DUKE UNIVERSITY;KOJIMA, KAIHEI;HEITMAN, JOSEPH;BAHN, YO-SUN