IMMUNOHISTOCHEMICAL METHODS FOR DETERMINING SIGNAL TRANSDUCTION ACTIVITY IN TUMORS
摘要
The method of the invention pertains to determining signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined ratio of expression levels of effector molecules in subcellular compartments with the receptor expression was found to have prognostic significance.
申请公布号
CA2650776(A1)
申请公布日期
2007.11.15
申请号
CA20072650776
申请日期
2007.05.07
申请人
YALE UNIVERSITY;HISTORX, INC.
发明人
DOLLED-FILHART, MARISA P.;GUSTAVSON, MARK;GILTNANE, JENNIFER;RIMM, DAVID L.;CAMP, ROBERT L.