Quinazoline derivatives as VEGF inhibitors

摘要

The invention relates to quinazoline derivatives of formula (I), wherein m is an integer from 1 to 3; R¹ represents halogeno or C_1-3alkyl; X¹ represents -O-; R² is selected from one of the following three groups: 1) C_1-5alkylR³ (wherein R³ is piperidinyl-4-yl which may bear one or two substituents selected from hydroxy, halogeno, C_1-4alkyl, C_1-4hydroxyalkyl and C_1-4alkoxy; 2) C_2-5alkenylR³ (wherein R³ is as defined hereinbefore); 3) C_2-5alkynylR³ (wherein R³ is as defined hereinbefore); and wherein any alkyl, alkenyl or alkynyl group may bear one or more substituents selected from hydroxy, halogeno and amino; and salts thereof; processes for their preparation, pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof as active ingredient. The compounds of formula (I) and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.