AMINOACID DERIVATIVES OF THIAZOLES AS INHIBITORS OF PI3 KINASE

摘要

Compounds of formula (I) are inhibitors of PI3 kinase activity, and useful in treatment of, inter alia, autoimmune, inflammatory and proliferative diseases; wherein s is 0 or 1; U is hydrogen or halogen; X is -(C=O)-, or an optionally substituted divalent phenylene, pyridinylene, pyrimidinylene, or pyrazinylene radical, or a bond; P is optionally substituted C<SUB>1</SUB>-C<SUB>6</SUB> alkyl and Z is -(CH<SUB>2</SUB>)<SUB>Z</SUB>-Y<SUP>1</SUP>-L<SUP>1</SUP>-R or Z is optionally substituted C<SUB>1</SUB>-C<SUB>6</SUB> alkyl and P is -(CH<SUB>2</SUB>)<SUB>Z</SUB>-Y<SUP>1</SUP>-L<SUP>1</SUP>-R; and z, Y<SUP>1</SUP>, L<SUP>1 </SUP>and R are as defined in the claims.