发明名称 |
Cell regulatory genes, encoded products, and uses related thereto |
摘要 |
This application describes the cloning of p63, a gene at chromosome 3q27-29, that bears homology to the tumor suppressor p53. The p63 gene encodes at least six different isotypes. p63 was detected in a variety of human and mouse tissue and demonstrates remarkably divergent activities, such as the ability to transactivate p53 reporter genes and induce apoptosis. Isotopes of p63 lacking a transactivation domain act as dominant negatives towards the transactivation by p53 and p63.
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申请公布号 |
US7294459(B1) |
申请公布日期 |
2007.11.13 |
申请号 |
US19980174493 |
申请日期 |
1998.10.15 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
YANG ANNIE;MCKEON FRANK |
分类号 |
C12Q1/68;A61K38/00;A61K39/00;C07H21/04;C07K14/435;C07K14/47;C07K16/18;C12N15/63;G01N33/50;G01N33/574 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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