<p>Disclosed is a coated macrolide antibiotic preparation which comprises a macrolide antibiotic having a group represented by the partial structural formula (I): [wherein R<SUP>2a</SUP> represents a hydrogen atom or a protecting group for a hydroxyl group] or a pharmaceutically acceptable salt thereof or a hydrate of the antibiotic or the salt, and which is coated with a coating agent comprising mainly a polyvinyl alcohol or a polyvinyl alcohol copolymer.</p>
