MITOCHONDRIA-TARGETED ANTIOXIDANT PRODRUGS AND METHODS OF USE
摘要
The present invention is a mitochondria-targeted antioxidant prodrug useful for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. Antioxidant prodrugs of the invention are produced by modifying an antioxidant to a fatty acid so that the resulting prodrug is targeted to and activated by an enzyme of mitochondrial fatty acid beta-oxidation.
申请公布号
WO2007062343(A3)
申请公布日期
2007.11.08
申请号
WO2006US61081
申请日期
2006.11.20
申请人
UNIVERSITY OF ROCHESTER;ANDERS, MARION, W.;ROBOTHAM, JAMES, L.;SHEU, SHEY-SHING