<p>The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivohalf-life of native factor FVIII.</p>
申请公布号
WO2007126808(A1)
申请公布日期
2007.11.08
申请号
WO2007US07560
申请日期
2007.03.29
申请人
BAXTER INTERNATIONAL INC;BAXTER HEALTHCARE S.A.;SIEKMANN, JUERGEN;VARADI, KATALIN;GRITSCH, HERBERT;TURECEK, PETER
发明人
SIEKMANN, JUERGEN;VARADI, KATALIN;GRITSCH, HERBERT;TURECEK, PETER