<p>A fragment of Gremlin having the sequence of amino acids shown in SEQ ID NO:2 or a functional subsequence of the fragment is described. The fragment is capable of altering BMP4 activity. Also provided is a polynucleotide encoding the fragment. Also disclosed is an assay for testing a molecule for Gremlin inhibitory activity. The invention also provides a method of inhibiting BMP4 activity.</p>
申请公布号
WO2007124486(A2)
申请公布日期
2007.11.01
申请号
WO2007US67221
申请日期
2007.04.23
申请人
CHILDRENS HOSPITAL LOS ANGELES;SHI, WEI;WARBURTON, DAVID