THE USE OF THE PROCESS OF INDUCTION OF DE NOVO SYNTHESIS OF P-GLYCOPROTEIN (P-GP) IN THE TREATMENT OF XENOBIOTIC-INDUCED INTOXICATIONS IN MAMMALS

摘要

The present invention concerns to the process of induction ofde novo synthesis of P-glycoprotein (P-gp) to be used as a treatment of xenobiotic-induced intoxications in mammals and, in particular, of paraquat (PQ)-induced intoxications (Fig. 3). It is shown, for the first time that the induction of de novo synthesis of P-gp, 2 hours after PQ exposure, led to a remarkable decrease of PQ accumulation in the lung to 40% of the group exposed only to PQ, and to an increase of its faecal excretion with the subsequent reversion of the toxicity, as shown by several biochemical and histopathological biomarkers of toxicity in just 24 hours.