发明名称 |
7-AZAINDOLES, PHARMACEUTICAL COMPOSITIONS AND THEIR THERAPEUTIC APPLICATIONS |
摘要 |
The present invention relates generally to compounds and compositions for the treatment of metabolic diseases and specifically, the present invention relates to compounds that therapeutically modulation and control lipid and/or carbohydrate metabolism and are thus suitable for the prevention and/or treatment of diseases such as type 2 diabetes, atherosclerosis, and the diverse manifestations thereof. The present invention relates to 7-azaindoles, their physiologically acceptable salts and functional derivatives thereof that exhibit a high degree of peroxisome proliferator-activated receptors (PPAR) agonist activity. Compounds of the present invention are described by formula I: in which the R-groups are herein defined, together with their pharmaceutically acceptable salts, therapeutic methods for their use and processes for their preparation. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved.
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申请公布号 |
US2007254908(A1) |
申请公布日期 |
2007.11.01 |
申请号 |
US20070681923 |
申请日期 |
2007.03.05 |
申请人 |
SANOFI-AVENTIS DEUTSCHLAND GMBH |
发明人 |
KEIL STEFANIE;GLIEN MAIKE;SCHAEFER HANS-LUDWIG;WENDLER WOLFGANG;BERNARDELLI PATRICK;TERRIER CORINNE;RONAN BAPTISTE |
分类号 |
A61K31/437;A61P3/00;A61P9/00;A61P29/00;C07D471/02 |
主分类号 |
A61K31/437 |
代理机构 |
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地址 |
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