发明名称 |
RNAi MEDICINE HAVING NO ADVERSE EFFECTS |
摘要 |
An RNAi reagent and a medicine that have no adverse effects such as interferon and/or cytotoxicity induction are provided. An shRNA used for sequence-specific RNA interference without interferon and/or cytotoxicity induction and a medicine and a reagent containing the shRNA are provided, such shRNA comprising a sense strand comprising a sequence homologous to a target sequence of the target mRNA and an antisense strand comprising a sequence complementary to the sequence of the sense strand and having an overhang comprising one or a plurality of G(s) at the 5' end of the sense strand.
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申请公布号 |
EP1849865(A1) |
申请公布日期 |
2007.10.31 |
申请号 |
EP20060712960 |
申请日期 |
2006.01.27 |
申请人 |
HAPLOPHARMA INC. |
发明人 |
TAKAKU, HIROSHI;KUROSAKI, NAOKO;YAMAGUCHI, KAZUYA;GONDAI, TAKUMA |
分类号 |
A61K48/00;A61P31/04;A61P31/10;A61P31/12;A61P35/00;C12N15/09;C12N15/11 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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