发明名称 |
USE OF THE ORNITHINE TRANSCARBAMYLASE (OTC), AS A MARKER FOR DIAGNOSING BRAIN DAMAGES |
摘要 |
The present invention pertains to the domain of brain diseases, and provides novel markers and methods for diagnosing a brain alteration in an individual, especially in patients suffering from neurodegenerative diseases such as Alzheimer's disease. The present invention also provides tools for evaluating the probability, for an individual, of developing the disease, as well as a target for identifying new drugs for treating neurodegenerative diseases such as Alzheimer's disease. In particular, the invention provides a genetic marker based on combination of two single nucleotide polymorphism, at positions -389 and -241 of the ornithine transcarbamylase (OTC) gene. |
申请公布号 |
WO2007119179(A2) |
申请公布日期 |
2007.10.25 |
申请号 |
WO2007IB02166 |
申请日期 |
2007.04.18 |
申请人 |
GENOSCREEN;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);AMOUYEL, PHILIPPE;LAMBERT, JEAN-CHARLES;FERREIRA, STEPHANIE |
发明人 |
AMOUYEL, PHILIPPE;LAMBERT, JEAN-CHARLES;FERREIRA, STEPHANIE |
分类号 |
C12Q1/68;A01K67/00 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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