Triazolobenzodiazepines and Their Use as Vasopressin Antagonists

摘要

Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein R represents H, C_1-6 alkyl, SO₂R¹, SO₂NR¹R², or COR¹; R¹ and R² independently represent C_1-6 alkyl; and Ring A represents a phenyl ring or a pyridinyl ring; may be useful in the treatment of anxiety, cardiovascular disease (including angina, atherosclerosis, hypertension, heart failure, edema, hypernatremia), dysmenorrhoea (primary and secondary), endometriosis, emesis (including motion sickness), intrauterine growth retardation, inflammation (including rheumatoid arthritis), mittlesmerchz, preclampsia, premature ejaculation, premature (preterm) labor and Raynaud's disease.