发明名称 |
REAGENTS, METHODS AND SYSTEMS FOR SELECTING A CYTOTOXIC ANTIBODY OR VARIANT THEREOF |
摘要 |
The present invention provides reagents, methods and systems for predicting the cytotoxic activity of an antibody or variant thereof comprising: determining a binding affinity of the antibody or variant thereof to a Fc activating receptor; determining a binding affinity of the antibody or variant thereof to a Fc inhibitory receptor, and calculating the ratio of said activating binding affinity to said inhibitory binding affinity (A/I ratio) , wherein the magnitude of said ratio is an indication of the cytotoxic activity of the antibody or variant thereof . The present invention also provides purified modified antibodies having altered A/I ratios as compared to the unmodified antibodies. |
申请公布号 |
WO2007055916(A3) |
申请公布日期 |
2007.10.25 |
申请号 |
WO2006US41791 |
申请日期 |
2006.10.27 |
申请人 |
THE ROCKEFELLER UNIVERSITY;RAVETCH, JEFFREY;FALK, NIMMERJAHN |
发明人 |
RAVETCH, JEFFREY;FALK, NIMMERJAHN |
分类号 |
A61K39/00;A61K39/395;G01N33/53 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|