发明名称 |
NANOPARTICLES COMPRISING A PDGF RECEPTOR TYROSINE KINASE INHIBITOR |
摘要 |
The present invention relates to nanoparticles comprising a platelet-derived growth factor (PDGF) receptor tyrosine kinase inhibitor, especially a PDGF receptor tyrosine kinase inhibitor having a water-solubility at 20°C between about 2.5 g / 100 ml and 250 g / 100 ml, more specifically nanoparticles comprising an N-phenyl-2-pyrimidine-amine derivative of formula (I), in which the symbols and substituents have the meanings as given herein above, in free form or in pharmaceutically acceptable salt form; to the intracellular delivery of PDGF receptor tyrosine kinase inhibitors such as Imatinib with bio-absorbable polymeric nanoparticles; the use of such nanoparticles in the manufacture of a pharmaceutical composition for the treatment of vascular smooth muscle cells growth diseases; to a method of treatment of warm-blooded animals suffering from vascular smooth muscle cells growth diseases; to a process to prepare such nanoparticles; to pharmaceutical compositions comprising such nanoparticles; and to drug delivery systems incorporating such nanoparticles for the prevention and treatment of vascular smooth muscle cells growth diseases. |
申请公布号 |
WO2007119601(A2) |
申请公布日期 |
2007.10.25 |
申请号 |
WO2007JP57024 |
申请日期 |
2007.03.23 |
申请人 |
KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION;EGASHIRA, KENSUKE |
发明人 |
EGASHIRA, KENSUKE |
分类号 |
A61K9/51;A61K31/506;A61L31/16 |
主分类号 |
A61K9/51 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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