| 摘要 |
A description of novel artificial transcription factors (ATFs) is provided having a non- peptidic DNA-binding domain, flexible linker, and an effector domain based on a small molecule compound. These ATFs are capable of modulating transcription from nucleic acids both in vitro and in vivo. Importantly, these novel ATFs are capable of targeting and modulating the transcription of native (endogenous) genes in vivo. Method for targeted regulation of gene expression and the development of new class of pharmaceuticals are also provided. |
