| 摘要 |
A process for the preparation of a compound of formula (I) or a salt thereof, both as the isomeric mixture and the individual isomers,
wherein Q is =CR 8 - or =N-; each R 1 , R 2 , R 3 and R 4 is independently selected from hydrogen, halogen, hydroxy; nitro; C 1 -C 6 alkyl optionally substituted with hydroxy; alkylthio C 1 -C 6 ; C 1 -C 6 alkoxy optionally substituted with halogen or C 1 -C 6 alkoxy; phenyl-C 1 -C 6 alkyl; phenyl-C 1 -C 6 alkoxy; and - N(RaRb) wherein each Ra and Rb is independently hydrogen or C 1 -C 6 alkyl or Ra and Rb, taken together with the nitrogen atom they are linked to, form a saturated heterocyclic ring; and
each R 5 , R 6 , R 7 and R 8 is independently selected from hydrogen, halogen, hydroxy; C1-C6 alkyl optionally substituted with hydroxy; alkylthio C 1 -C 6 ; C 1 -C 6 alkoxy optionally substituted with halogen; C 1 -C 6 alkyl-carbonyl, C 1 -C 6 alkoxy-carbonyl, and oxazol-2-yl; comprising converting a compound of formula (IV), or a salt thereof,
wherein Q, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined above,
to said compound of formula (I), or a salt thereof, in the presence of a catalyst, if necessary in an organic solvent; and, if desired, converting a compound of formula (I) to a salt thereof to another compound of formula (I); and/or, if desired, resolving an isomeric mixture of a compound of formula (I) in the individual isomers.
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