| 摘要 |
A process for the preparation of 4"-deoxyerythromycins, having formula (I), wherein R is H or OH, Rp is H or acetyl, and R1 is H or loweralkyl; by treatment of the 2'-O-acetyl-4"-imidazolylthionocarbonyl - erythromycin starting material with the radical initiator 4,4'-azobis-(4-cyanovaleric acid), H3PO2 and an organic base in a water- miscible solvent other than an alcohol, and optionally eliminating the 2'-O-acetyl group. In a preferred embodiment, the water-miscible solvent is an alcohol and the deoxygenation and deacetylation is carried out in one step.
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