METHOD FOR TREATMENT OF MACULAR DEGENERATION AND RELATED EYE CONDITIONS

摘要

PROBLEM TO BE SOLVED: To provide an AIM-lipid complex for treating age-related macular degeneration and related conditions. SOLUTION: A method for treatment of macular degeneration comprises administering to a mammal in need thereof, an Apo A-I Milano ("AIM") protein in a soluble or particulate form or an AIM:lipid complex. An Apo A-I Milano can be complexed with a lipid or phospholipid. The invention includes the treatment with Apo A-I Milano particles containing a suitable phospholipid. In one embodiment, the phospholipid is phospholipid POPC (1-palmitoyl-2-oleoyl phosphatidylcholine) that is co-administered with various apolipoproteins in a typical therapeutic particle, and the Apo A-I Milano is administered to the mammal in need thereof. COPYRIGHT: (C)2008,JPO&INPIT