发明名称 |
SOL-GEL DERIVED SILICA POLYMERS FOR THE SUSTAINED RELEASE OF PROTEINS |
摘要 |
<p>The use of wet silica based polymers obtained by the sol-gel technology for the entrapment and sustained release of macromolecular bioactive compounds and, more specifically, proteins with pharmaceutical applications, is disclosed. The wet-gel formulations are obtained by a method which comprises mixing an alkoxysilane solution, a gelling catalyst and a buffered water solution of a biologically active principle and subsequently casting the thus-obtained mixture into suitable containers without previous or subsequent partial or complete removal of the water solvent; the containers are then sealed after casting in order to preserve the wet state of the gel. The wet-gel formulations may then be used for the manufacture of a ready-to-use injectable solution by mixing the silica wet-gel formulation with water or with a physiological water solution.</p> |
申请公布号 |
WO2007115860(A1) |
申请公布日期 |
2007.10.18 |
申请号 |
WO2007EP51762 |
申请日期 |
2007.02.23 |
申请人 |
BIO-KER SRL;TONON, GIANCARLO;MORPURGO, MARGHERITA |
发明人 |
TONON, GIANCARLO;MORPURGO, MARGHERITA |
分类号 |
C08G77/02 |
主分类号 |
C08G77/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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