发明名称 |
PEPTIDES AS SOLUBILIZING EXCIPIENTS FOR TRANSFORMING GROWTH FACTOR BETA PROTEINS |
摘要 |
The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension of the T266 isoform of rhBMP-2 has properties that enhance the solubility of proteins. The invention also relates to methods of resolubilizing a protein that has precipitated, by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2. The invention also relates to methods of increasing the solubility of a protein by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2.
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申请公布号 |
US2007244050(A1) |
申请公布日期 |
2007.10.18 |
申请号 |
US20070757807 |
申请日期 |
2007.06.04 |
申请人 |
WYETH |
发明人 |
NICHOLS PILARIN E.L.;PEREZ-RAMIREZ BERNARDO |
分类号 |
A61K48/00;A61K38/07;A61K38/18;C07K7/08;C07K14/00;C07K14/51 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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