发明名称 |
Optically active 2-allylcarboxylic acid derivative and process for producing the same |
摘要 |
The present invention provides a process for producing an optically active 2-allylcarboxylic acid derivative, which is useful as a pharmaceutical intermediate, from readily available and inexpensive starting materials by the process which can be practiced on a commercial scale in a simple and easy manner, and certain 2-allylcarboxamide derivatives, which are novel and important intermediates in that process. An N-allylcarboxamide derivative undergoes rearrangement reaction diastereoselectively in the presence of a base to give a 2-allylcarboxamide derivative, the resulting derivative is subjected to a carbamation reaction and solvolysis to give an optically active 2-allylcarboxylic acid ester, and then the ester obtained is stereoselectively hydrolyzed using an enzyme to produce 2-allylcarboxylic acid having a high optical purity. In addition, the present invention provides a 2-allylcarboxamide derivative compound which is a novel intermediate in the process of the present invention.
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申请公布号 |
US7282605(B2) |
申请公布日期 |
2007.10.16 |
申请号 |
US20050553394 |
申请日期 |
2005.12.14 |
申请人 |
ONO PHARMACEUTICAL CO., LTD. |
发明人 |
OKURO KAZUMI;AMANO SUSUMU;KIZAKI NORIYUKI;TAKESUE TERUAKI;MITSUDA MASARU;ITO NORIYUKI;YASOHARA YOSHIHIKO |
分类号 |
C07C291/00;C07C51/00;C07C67/20;C07C233/05;C07C233/18;C07C237/16;C07C237/18;C07C237/20;C07C271/64;C12P7/40;C12P41/00 |
主分类号 |
C07C291/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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