4, 5-DIHYDROMACBECIN DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER OR B-CELL MALIGNANCIES.

摘要

The present invention relates to 4,5-dihydromacbecin analogues according to the formula (IA) or (IB) below, or a pharmaceutically acceptable salt there of: wherein: R<SUB>1</SUB> represents H or CONH<SUB>2</SUB>. that are useful, e.g. in the treatment of cancer,B-cell malignancies malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and / or prophylaxis of cancer or B-cell malignancies.