摘要 |
The present invention relates to compounds according to the formula I: Where R<SUP>a</SUP> is H or an optionally OH-substituted C<SUB>1</SUB>-C<SUB>3</SUB> alkyl; R<SUB>1</SUB> is OR<SUP>1</SUP>, an optionally substituted C<SUB>4-12</SUB> carbocyclic group which may be saturated or unsaturated (including aromatic) or an optionally substituted heterocyclic group; R<SUP>1</SUP> is an optionally substituted C<SUB>1</SUB>-C<SUB>14</SUB> hydrocarbyl group or an optionally substituted heterocyclic group;; R<SUB>2</SUB> , R<SUB>3</SUB> and R<SUB>4</SUB> are each independently H, an optionally substituted C<SUB>1</SUB>-C<SUB>4</SUB> alkyl group (preferably CH<SUB>3</SUB>, CH<SUB>2</SUB>CH<SUB>3</SUB> or CF<SUB>3</SUB>), halogen (preferably F, Cl, Br), OR, CN, NO<SUB>2</SUB>, a C<SUB>1</SUB>-C<SUB>6</SUB> thioether, a C<SUB>1</SUB>-C<SUB>6</SUB> thioester group, an optionally substituted CO<SUB>2</SUB>R group, an optionally substituted COR group or an optionally substituted OCOR group (preferably R<SUB>4</SUB> is H); R is H or an optionally substituted C<SUB>1</SUB>-C<SUB>6</SUB> alkyl group; RHET is an optionally substituted heterocyclic group; and pharmaceutically acceptable salts, solvates or polymorphs thereof. |
申请人 |
YALE UNIVERSITY;JORGENSEN, WILLIAM, L.;RUIZ-CARO, JULIANA;HAMILTON, ANDREW, D. |
发明人 |
JORGENSEN, WILLIAM, L.;RUIZ-CARO, JULIANA;HAMILTON, ANDREW, D. |