| 摘要 |
The inventive composition comprises the water-insoluble fraction of cells of the yeast producer of a heterologous hydrophobic cytokine protein, solubilzer and water, wherein a target hydrophobic cytokine protein has been synthesized in said producer. In particular the cytokine protein is interleukine-2 (IL-2) and the yeast producer is the Saccharomyces cerevisiae strain deposited as No Y-791in the All-Russian Collection of Industrial Microorganisms. Said composition exhibits an immunomodulating activity and can be used in immune-oriented therapy and, in particular, for treating oncologic, infectious, autoimmune and allergic diseases. A composition comprising the water-insoluble fraction of destroyed cells of the heterologous hydrophobic protein-cytokine yeast producer, in which the target hydrophobic protein-cytokine has been synthesised, is also disclosed. Said composition is not active itself and can be used for producing the immunomodulating composition by adding the solubilzer and water thereto. |
