| 摘要 |
FIELD: oncology and biotechnology. ^ SUBSTANCE: invention concerns conjugates used for treatment of malignant tumor. Conjugate includes staphylococcal or streptococcal wild-type superantigen or modified superantigen and antibody constituent. Bacterial superantigen is modified to reduce serum reactivity with preserved its antigenic activity. Amino acid sequence of superantigen incorporates A-E regions determining binding to TCR and MHC molecules class II. Invention is directed to preparing antitumor drug and also to preparing pharmaceutical composition. ^ EFFECT: use of the conjugate according to invention activate immune system and, therefore, resistance of mammalian against malignant tumor. ^ 67 cl, 11 dwg, 1 tbl, 11 ex |
