| 发明名称 |
NOVEL APOPTOSIS-MODULATING PROTEIN, DNA ENCODING THE PROTEIN AND METHOD OF USE THEREOF |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a novel family of an apoptosis-modulating protein; nucleotide sequences, amino acid residue sequences, and derivatives of the sequences; and a method for using these substances. <P>SOLUTION: The present invention provides a substantially purified DNA encoding novel Bcl-2 homologs, termed Cdn-1, Cdn-2 and Cdn-3 and their derivatives; a recombinant cell and a transgenic animal expressing the Cdn-1 and Cdn-2 nucleotides; substantially purified Cdn-1 and Cdn-2 proteins and their compositions; diagnostic and therapeutic methods using the nucleotides and the proteins; a pharmaceutical agent stimulating the expression of Cdn-1 and Cdn-2 and the activity and interaction of the protein; a method for screening a pharmaceutical agent modulating the expression of Cdn-1 and Cdn-2 and the activity and interaction of the protein; and a method for screening a protein interacting with Cdn. <P>COPYRIGHT: (C)2008,JPO&INPIT |
| 申请公布号 |
JP2007252391(A) |
申请公布日期 |
2007.10.04 |
| 申请号 |
JP20070155798 |
申请日期 |
2007.06.12 |
| 申请人 |
TANOX INC |
发明人 |
KIEFER MICHAEL C;BARR PHILIP J |
| 分类号 |
A01K67/027;C12N15/09;A61K38/00;A61P1/00;A61P3/04;A61P3/10;A61P7/06;A61P9/00;A61P9/10;A61P13/08;A61P17/14;A61P25/00;A61P27/02;A61P31/04;A61P31/12;A61P35/00;A61P37/02;A61P37/06;C07H21/04;C07K14/47;C07K16/18;C12N5/10;C12N15/13;C12N15/85;C12P21/02;C12P21/08;C12Q1/68;C12R1/91;G01N33/53 |
主分类号 |
A01K67/027 |
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