PROCESS FOR THE PREPARATION OF A HOT-MELT EXTRUDED LAMINATE
摘要
A process for the preparation of a bioadhesive laminate comprising a hot-melt extruded reservoir layer and a hot-melt extruded backing layer is provided. The reservoir layer comprises a thermoplastic bioadhesive composition containing an active agent. An active agent-containing thermoplastic bioadhesive hydrophilic composition is hot-melt coextruded with a hydrophobic composition to form at least a bi-layered laminate. The hydrophilic composition and the hydrophobic composition have at least one polymer in common. In addition, the melt flow index of the hydrophobic composition is within 50% of the melt flow index of the hydrophilic composition. As a result, the laminate has a uniform transverse cross-section and/or a uniform longitudinal cross-section throughout a major of the length of the laminate. Moreover, when the laminate is divided into unit doses of approximately the same size, they have a high degree of content uniformity with respect to the active agent(s) present therein.
申请公布号
WO2007112285(A2)
申请公布日期
2007.10.04
申请号
WO2007US64713
申请日期
2007.03.22
申请人
AUXILIUM PHARMACEUTICALS, INC.;CROWLEY, MICHAEL, M.;KEEN, JUSTIN, M.;KOLENG, JOHN, J.;ZHANG, FENG