| 摘要 |
A pharmaceutical composition including a combination of a sub-therapeutic amount of the S isomer of ibuprofen, also referred to as dexibuprofen, or a pharmaceutically acceptable salt or derivative thereof, an opiate or a pharmaceutically acceptable salt or derivative thereof, and a centrally-acting cyclo-oxygenase inhibitor, as active ingredients, and a pharmaceutically acceptable carrier. A typical combination includes paracetamol, dexibuprofen and codeine, with the dexibuprofen being provided in an amount to give a daily dose of 100 mg or less. A method of treatment using a combination of a sub-therapeutic amount of dexibuprofen, an opiate and a centrally-acting cyclo-oxygenase inhibitor is also described. |
