| 发明名称 |
Chemical compounds and pharmaceutical compositions as cathepsin S inhibitors |
| 摘要 |
Disclosed is a compound of formula I in which: X1 is -NHC(R1)(R2)X3 or -NHX4; X2 is -H, -F, -OH, -OR4, -NHR15 or -NR17R18; X7 is H or X2 and X7 both represent fluoro; and the remainder of the substituents are as described in the specification. Compounds of the type disclosed are useful in the treatment of diseases associated with Cathepsin S activity.
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| 申请公布号 |
NZ528944(A) |
申请公布日期 |
2007.09.28 |
| 申请号 |
NZ20020528944 |
申请日期 |
2002.06.03 |
| 申请人 |
AXYS PHARMACEUTICALS, INC.;AVENTIS PHARMACEUTICALS INC. |
发明人 |
GRAUPE, MICHAEL;LI, JIAYAO;LINK, JOHN O;ZIPFEL, SHEILA;TIMM, ANDREAS P;ALDOUS, DAVID J;THURAIRATNAM, SUKANTHINI |
| 分类号 |
C07D295/18;A61K31/165;A61K31/277;A61K31/341;A61K31/351;A61K31/381;A61K31/397;A61K31/40;A61K31/423;A61K31/4245;A61K31/426;A61K31/427;A61K31/428;A61K31/437;A61K31/4453;A61K31/4468;A61K31/454;A61K31/495;A61K31/5375;A61K31/5377;A61K31/55;A61P1/02;A61P13/12;A61P19/02;A61P21/04;A61P29/00;A61P33/06;A61P35/00;A61P43/00;C07C233/31;C07C255/29;C07C255/44;C07C255/46;C07C271/12;C07C271/16;C07C271/22;C07C271/24;C07C317/44;C07C317/46;C07C317/48;C07D205/04;C07D207/08;C07D207/16;C07D211/66;C07D223/08;C07D223/12;C07D239/08;C07D263/56;C07D271/06;C07D271/10;C07D277/28;C07D277/64;C07D277/82;C07D295/185;C07D295/20;C07D295/205;C07D307/14;C07D309/14;C07D333/24;C07D413/12;C07D413/14;C07D417/12;C07D498/04;(IPC1-7):C07C317/46;A61K31/16;C07F7/18 |
主分类号 |
C07D295/18 |
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