Aryl ureido derivatives and their medical use

摘要

Disclosed are aryl ureido benzoic acid derivatives that are useful as selective and non-competitive antagonists of the ionotropic GluR5 receptor. Due to their biological activity, these aryl ureido derivatives are considered useful for treating diseases that are responsive to modulation of an aspartate or a glutamate receptor. The disclosure also relates to pharmaceutical compositions comprising these aryl ureido compounds, and their use for treating diseases or disorders or conditions responsive to modulation of an aspartate or a glutamate receptor.