RECOMBINANT MVA VIRUS AND ITS USE

摘要

PROBLEM TO BE SOLVED: To provide a recombinant vaccinia virus Ankara (MVA) usable as an efficient and extremely safe expression vector and provide a method for the easy, efficient and safe production of a polypeptide (e.g. antigen or treating agent), recombinant virus for vaccine and virus vector for gene therapy.

SOLUTION: The invention provides a recombinant MVA virus containing a foreign gene inserted at a naturally occurring deletion site in the MVA genome and enabling expression in the genome, and a recombinant MVA virus containing HIVnef antigen or antigen determining group and enabling the expression in the virus wherein the HIVnef gene is under the transcription control of the initial/late promoter P7.5 of vaccinia virus.

COPYRIGHT: (C)2007,JPO&INPIT