摘要 |
<p>Compounds of formula (I) have antibacterial activity wherein R represents hydrogen or 1, 2 or 3 optional substituents; W is =C(R<SUB>1</SUB>)- or =N-; R<SUB>1</SUB> is hydrogen or an optional substituent and R<SUB>2</SUB> is hydrogen, methyl, or fluorine; or R<SUB>1</SUB> and R<SUB>2</SUB> taken together are -CH<SUB>2</SUB>-, -CH<SUB>2</SUB>CH<SUB>2</SUB>-, -O-, or, in either orientation, -O- CH<SUB>2</SUB>- Or -OCH<SUB>2</SUB>CH<SUB>2</SUB>-; R<SUB>3</SUB> is a radical of formula -(Alk<SUP>1</SUP>)<SUB>m</SUB>-(Z)<SUB>p</SUB>-(Alk<SUP>2</SUP>)<SUB>n</SUB>-Q wherein m, p and n are independently 0 or 1, provided that at least one of m, p and n is 1, Z is -O-, -S-, -S(O)-, -S(O<SUB>2</SUB>)-, -NH-, -N(CH<SUB>3</SUB>)-, -N(CH<SUB>2</SUB>CH<SUB>3</SUB>)-, -C(=O)-, -O-(C=O)-, -C(=O)-O-, or an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted divalent bicyclic heterocyclic radical having 5 to 10 ring atoms; Alk<SUP>1</SUP> and Alk<SUP>2</SUP> are optionally substituted C<SUB>1</SUB>C<SUB>6</SUB> alkylene, C<SUB>2</SUB>-C<SUB>6</SUB> alkenylene, or C<SUB>2</SUB>-C<SUB>6</SUB> alkynylene radicals, which may optionally terminate with or be interrupted by -O-, -S-, -S(O)-, -S(O<SUB>2</SUB>)-, -NH-, -N(CH<SUB>3</SUB>)-, or -N(CH<SUB>2</SUB>CH<SUB>3</SUB>)-; and Q is hydrogen, halogen, nitrile, or hydroxyl or an optionally substituted monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted bicyclic heterocyclic radical having 5 to 10 ring atoms.</p> |
申请人 |
PROLYSIS LTD;BROWN, DAVID, RYALL;COLLINS, IAN;CZAPLEWSKI, LLOYD, GEORGE;HAYDEN, DAVID, JOHN |
发明人 |
BROWN, DAVID, RYALL;COLLINS, IAN;CZAPLEWSKI, LLOYD, GEORGE;HAYDEN, DAVID, JOHN |