摘要 |
Compounds represented by formula 1: wherein R<SUP>1 </SUP>is H, halogen, (C<SUB>1-4</SUB>)alkyl, O(C<SUB>1-4</SUB>)alkyl, and haloalkyl; R<SUP>2 </SUP>is H or methyl; R<SUP>3 </SUP>is H or (C<SUB>1-4</SUB>)alkyl; R<SUP>4 </SUP>is H or (C<SUB>1-4</SUB>)alkyl; R<SUP>5 </SUP>is (C<SUB>1-4</SUB>)alkyl, (C<SUB>1-4</SUB>)alkyl(C<SUB>3-7</SUB>)cyclo-alkyl or (C<SUB>3-7</SUB>)cycloalkyl; and W is a fused phenyl-5 or 6-membered heterocycle having one or two heteroatoms selected from N or S; or W is phenyl, 1,1'-biphenyl, 2,3-dihydro-1H-indene, 1,2,3,4-tetrahydronaphthyl, or naphthyl; said W being optionally substituted with (C<SUB>1-4</SUB>)alkyl, which in turn can be optionally substituted with a carboxy or (C<SUB>1-4</SUB>)alkoxycarbonyl, or a salt or ester thereof. The compounds have inhibitory activity against Wild Type, single and double mutant strains of HIV.
|