发明名称 |
BROADLY CROSS-REACTIVE NEUTRALIZING ANTIBODIES AGAINST HUMAN IMMUNODEFICIENCY VIRUS SELECTED BY ENV-CD4-CO-RECEPTOR COMPLEXES |
摘要 |
The present invention features antibodies and antibody fragments that specifically bind a CD4-inducible HIV gp120 epitope that is enhanced by binding a co-receptor for HIV, such as CCR5 or CXCR4, and pharmaceutical compositions comprising the antibodies or antibody fragments. The invention also features nucleic acids encoding the antibodies or antibody fragments, pharmaceutical compositions comprising the nucleic acids encoding the antibodies or antibody fragments, vectors comprising the nucleic acids, and cells comprising the vectors. The invention further features methods of identifying antibodies or antibody fragments with broadly neutralizing activity against HIV. The invention also features methods of inhibiting HIV entry into cells and methods of inhibiting replication of HIV in mammals, using the antibodies and nucleic acids of the invention.
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申请公布号 |
US2007212349(A1) |
申请公布日期 |
2007.09.13 |
申请号 |
US20070748992 |
申请日期 |
2007.05.15 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
DIMITROV DIMITER S.;MOULARD MAXIME;XIAO XIADONG;SHU YUUEI;PHOGAT SANJAY K.;ZHANG MEI-YUN;BURTON DENNIS |
分类号 |
A61K39/395;C07K14/73;C07K16/10;C12N5/06;C12N5/16;C12P21/04;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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主权项 |
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地址 |
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