发明名称 |
INFLAMMATORY CYTOKINE INHIBITOR |
摘要 |
<p>A search was conducted for functional antibodies that endogenously regulate cytokines, focusing on the relationship between inflammatory diseases and cytokines. Mice were immunized with a human peripheral blood monocyte fraction and the obtained antibodies were examined for a cytokine-regulating effect. As a result, of these antibodies, antibody #33 was confirmed to inhibit the production of numerous typical inflammatory cytokines. When, at the same time, the promoting effect of antibody #33 on IL-10 production was examined, it was revealed that antibody #33 has an effect of accelerating IL-10 production but no activity to induce an excessive IL-10 production. The antigen of this promising antibody was verified to be CD61. Therefore, it is conceivable that when anti-CD61 antibodies are applied to the treatment of inflammatory diseases, they would become pharmaceuticals with both a definite efficacy and a high safety.</p> |
申请公布号 |
EP1712566(A4) |
申请公布日期 |
2007.09.12 |
申请号 |
EP20050703804 |
申请日期 |
2005.01.19 |
申请人 |
MEDICAL AND BIOLOGICAL LABORATORIES CO., LTD. |
发明人 |
OKABE, AYAKO;TOJI, SHINGO;KISHI, YOSHIRO;YAHARA, ICHIRO |
分类号 |
A61K38/00;A61K39/395;A61K45/00;A61P29/00;C07K16/28;C12N15/09;C12N15/13;C12Q1/02;G01N33/15;G01N33/50;G01N33/53;G01N33/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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