METHOD FOR THE PREPARATION OF 2'-DEOXY-2',2'-DIFLUOROCYTIDINE
摘要
This invention relates to an improved method for stereoselectively preparing 2¢¥-deoxy-2¢¥,2¢¥-difluorocytidine of formula (I), which comprises the steps of reacting a 1-halo ribofuranose compound of formula (III) with a nucleobase of formula (IV) in a solvent to obtain a nucleoside of formula (II) with removing the silyl halide of formula (V) produced during the reaction; and deprotecting the nucleoside of formula (II) to obtain 2¢¥-deoxy-2¢¥,2¢¥-difluorocytidine of formula (I).
申请公布号
EP1831236(A1)
申请公布日期
2007.09.12
申请号
EP20050823850
申请日期
2005.12.29
申请人
HANMI PHARM. CO., LTD.
发明人
LEE, JAEHEON;PARK, GHA SEUNG;LEE, MOONSUB;BANG, HYO-JEONG;LEE, JAE CHUL;KIM, CHEOL KYONG;CHOI, CHANG-JU;KIM, HAN KYONG;LEE, HOE CHUL;CHANG, YOUNG-KIL;LEE, GWAN SUN