| 摘要 |
Disclosed are suspensions of gas microbubbles immobilised within a frozen aq ueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by a n evanescent envelope or a tangible membrane. The suspensions, when in liquid form, are injectable and useful as a contrast agent in ultrasonic imaging of blood pool and tissue of living beings. The gas microb ubbles are immobilised within the carrier by freezing a suspension of microbubbles with average sizes below 50 .mu.m, preferably bel ow 10 .mu.m and more preferably between 2 .mu.m and 8 .m u.m, to a temperature between -1.degree.C and -76.degree.C and maintaining this temper ature for prolonged periods of time. The microbubbles ma y be stabilised by a surfactant such as a lamellar phospholipid or may comprise a membrane m ade of synthetic or natural polymer or protein. A method of cold storage of microbubble suspensions as well as their use is also disc losed.
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