| 摘要 |
It comprises new substituted heterocyclic methylphenyl boronic acids and their derivatives and also its preparation process. It also comprises a preparation process of Angiotensin II (A-II) receptor antagonists from such intermediates. The process includes the step of reacting the new substituted heterocyclic methylphenyl boronic compounds with a (halophenyl)tetrazole compound which proceeds with high yields. It allows to prepare the compounds of the present invention from a common intermediate compound, a N-protected-5-(2-halogenphenyl)-1H-tetrazole, by a process which is particularly advantageous in its practical industrial realization because it avoids the use of azide derivatives and also the use of expensive biphenyl intermediates.
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